- The first local implantation of a pacemaker (1992)
- The first local cardiac catheterization and angioplasty (1996)
- The first implantation of a cardiac defibrillator in the Caribbean (1998)
- The first implantation of a biventricular pacemaker with defibrillator in the Caribbean (2001)
- Installation of the first local 16 slice CT Scanner in the Caribbean (2003)
- Introduction of the first state of the art radiation center capable of delivering IMRT (intensity modulated radiation therapy) and high dose remote after-loading brachytherapy (HDR) (2004)
- Introduced Digital Mammography (2008)
- The delivery of the first stem cell treatment for a medical tourist (2012)
- Opened the Partners Clinical Research (2013) which is the largest actively enrolling clinical trial research site in the Caribbean.
- Opened Partners Stem Cell Center (2013) which is a leading edge heart and peripheral stem cell infusion center.
- Opened in 2015 in partnership with the government of Antigua the state of the art cancer care/infusion/radiology centersthe Cancer Center Eastern Caribbean
- Opened in 2018 Ambulatory Surgical Hospital and Interventional Center meeting all US standards and protocols with the unique capability to have patients stay overnight. Will soon offer US and Canadian citizens cochlear implants and neural implants for Parkinson's/Epilepsy and Essential Tremors performed by visiting US faculty.
- Expanded to international US patient programs in August 2019 to include expensive pills-injections / Chemo and non-chemo infusions for US employees/union members, paid for by their Employer/Union/TPA or Stop Loss carrier.


